Trofoblasto, impronta y conflicto genómico en Gineco-Obstetricia.

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  • Author(s): Bustos Vidal, Juan Carlos1
  • Source:
    Revista Chilena de Obstetricia y Ginecología. jun2015, Vol. 80 Issue 3, p269-274. 6p.
  • Additional Information
    • Alternate Title:
      Trophoblast, Imprinting and Genomic Conflict in Obstetrics and Gynecology.
    • Subject Terms:
    • Abstract:
      The theory of Genomic Conflict is part of evolutionary biology and acts in mammals through the mechanism of genetic imprinting, these genes play a central role in fetal and trophoblastic development producing a balance between fetal nutritional requirements (genes with paternal imprinting) and maternal supply (genes with maternal imprinting). The imbalance of these genes has implications in the pathogenesis of various diseases in Obstetrics and Gynecology: in Fetal Medicine (preeclampsia, gestational diabetes, Beckwith- Wiedemann syndrome), oncology (complete and partial hydatiform mole, teratomas) and fertility. A case of placental mesenchymal dysplasia associated with Beckwith-Wiedemann is presented. [ABSTRACT FROM AUTHOR]
    • Abstract:
      La teoría del Conflicto Genómico es parte de la biología evolutiva y actúa en los mamíferos a través del mecanismo de impronta genética, estos genes cumplen un rol central en el desarrollo fetal y del trofoblasto contribuyendo a un balance entre los requerimientos nutricionales fetales (genes con impronta paterna) y el aporte materno (genes con impronta materna). El desbalance de estos genes tiene implicancias en la etiopatogenia de diversas patologías en Gineco-Obstetricia: en Medicina Fetal (preeclampsia, diabetes gestacional, síndrome de Beckwith-Wiedemann), oncología (mola completa, mola incompleta, teratomas) y fertilidad. Se presenta un caso de displasia mesenquimática placentaria asociado a Beckwith-Wiedemann. [ABSTRACT FROM AUTHOR]
    • Abstract:
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