Magnetic mechanism for the biological functioning of hemoglobin

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  • Additional Information
    • Publication Date:
      2019
    • Collection:
      Condensed Matter
      Physics (Other)
    • Abstract:
      The role of magnetism in the biological functioning of hemoglobin has been debated since its discovery by Pauling and Coryell in 1936. The hemoglobin molecule contains four heme groups each having a porphyrin layer with a Fe ion at the center. Here, we present combined density-functional theory and quantum Monte Carlo calculations for an effective model of Fe in a heme cluster. In comparison with these calculations, we analyze the experimental data on human adult hemoglobin (HbA) from the magnetic susceptibility, Mossbauer and magnetic circular dichroism (MCD) measurements. In both the deoxygenated (deoxy) and the oxygenated (oxy) cases, we show that local magnetic moments develop in the porphyrin layer with antiferromagnetic coupling to the Fe moment. Our calculations reproduce the magnetic susceptibility measurements on deoxy and oxy-HbA. For deoxy-HbA, we show that the anomalous MCD signal in the UV region is an experimental evidence for the presence of antiferromagnetic Fe-porphyrin correlations. The various important properties of hemoglobin are explained based on the antiferromagnetic correlations including the Bohr effect and cooperativity. This analysis shows that magnetism is involved in a fundamental way in the functioning of hemoglobin.
    • Accession Number:
      edsarx.1911.05442
  • Citations
    • ABNT:
      MAYDA, S. et al. Magnetic mechanism for the biological functioning of hemoglobin. [s. l.], 2019. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsarx&AN=edsarx.1911.05442&custid=s6224580. Acesso em: 24 jan. 2020.
    • AMA:
      Mayda S, Kandemir Z, Bulut N, Maekawa S. Magnetic mechanism for the biological functioning of hemoglobin. 2019. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsarx&AN=edsarx.1911.05442&custid=s6224580. Accessed January 24, 2020.
    • APA:
      Mayda, S., Kandemir, Z., Bulut, N., & Maekawa, S. (2019). Magnetic mechanism for the biological functioning of hemoglobin. Retrieved from http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsarx&AN=edsarx.1911.05442&custid=s6224580
    • Chicago/Turabian: Author-Date:
      Mayda, Selma, Zafer Kandemir, Nejat Bulut, and Sadamichi Maekawa. 2019. “Magnetic Mechanism for the Biological Functioning of Hemoglobin.” http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsarx&AN=edsarx.1911.05442&custid=s6224580.
    • Harvard:
      Mayda, S. et al. (2019) ‘Magnetic mechanism for the biological functioning of hemoglobin’. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsarx&AN=edsarx.1911.05442&custid=s6224580 (Accessed: 24 January 2020).
    • Harvard: Australian:
      Mayda, S, Kandemir, Z, Bulut, N & Maekawa, S 2019, ‘Magnetic mechanism for the biological functioning of hemoglobin’, viewed 24 January 2020, .
    • MLA:
      Mayda, Selma, et al. Magnetic Mechanism for the Biological Functioning of Hemoglobin. 2019. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsarx&AN=edsarx.1911.05442&custid=s6224580.
    • Chicago/Turabian: Humanities:
      Mayda, Selma, Zafer Kandemir, Nejat Bulut, and Sadamichi Maekawa. “Magnetic Mechanism for the Biological Functioning of Hemoglobin,” 2019. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsarx&AN=edsarx.1911.05442&custid=s6224580.
    • Vancouver/ICMJE:
      Mayda S, Kandemir Z, Bulut N, Maekawa S. Magnetic mechanism for the biological functioning of hemoglobin. 2019 [cited 2020 Jan 24]; Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsarx&AN=edsarx.1911.05442&custid=s6224580