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Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling

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Author(s): Fulzele, Keertik; Krause, Daniela S.; Panaroni, Cristina; Saini, Vaibhav; Barry, Kevin J.; Liu, Xiaolong; Lotinun, Sutada; Baron, Roland; Bonewald, Lynda; Feng, Jian Q.; Chen, Min; Weinstein, Lee S.; Wu, Joy Y.; Kronenberg, Henry M.; Scadden, David T.; Divieti Pajevic, Paola
Source:
Blood; February 2013, Vol. 121 Issue: 6 p930-939, 10p

Additional Information
- Abstract:
  Key PointsDeletion of Gsα in osteocytes induces severe osteopenia and a dramatic expansion of cells of the myeloid lineage.Osteocytes regulate hematopoiesis and specifically contribute to myelopoiesis by secreting proliferative factors such as G-CSF.