Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Publication Year:
      2019
    • Author-Supplied Keywords:
      cerebral amyloid angiopathy
      neuroprotection
      taxifolin
      triggering receptor expressed on myeloid cell 2
    • Abstract:
      Cerebral amyloid angiopathy (CAA) results from amyloid-β deposition in the cerebrovasculature. It is frequently accompanied by Alzheimer's disease and causes dementia. We recently demonstrated that in a mouse model of CAA, taxifolin improved cerebral blood flow, promoted amyloid-β removal from the brain, and prevented cognitive dysfunction when administered orally. Here we showed that taxifolin inhibited the intracerebral production of amyloid-β through suppressing the ApoE-ERK1/2-amyloid-β precursor protein axis, despite the low permeability of the blood- brain barrier to taxifolin. Higher expression levels of triggering receptor expressed on myeloid cell 2 (TREM2) were associated with the exacerbation of inflammation in the brain. Taxifolin suppressed inflammation, alleviating the accumulation of TREM2- expressing cells in the brain. It also mitigated glutamate levels and oxidative tissue damage and reduced brain levels of active caspases, indicative of apoptotic cell death. Thus, the oral administration of taxifolin had intracerebral pleiotropic neuroprotective effects on CAA through suppressing amyloid-β production and beneficially modulating proinflammatory microglial phenotypes. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • ISSN:
      00278424
    • Accession Number:
      136477257
  • Citations
    • ABNT:
      TAKAYUKI INOUE et al. Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy. Proceedings of the National Academy of Sciences of the United States of America, [s. l.], v. 116, n. 20, p. 10031, 2019. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=136477257&custid=s6224580. Acesso em: 18 fev. 2020.
    • AMA:
      Takayuki Inoue, Satoshi Saito, Masashi Tanaka, et al. Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy. Proceedings of the National Academy of Sciences of the United States of America. 2019;116(20):10031. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=136477257&custid=s6224580. Accessed February 18, 2020.
    • APA:
      Takayuki Inoue, Satoshi Saito, Masashi Tanaka, Hajime Yamakage, Toru Kusakabe, Akira Shimatsu, Masafumi Ihara, & Noriko Satoh-Asahara. (2019). Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy. Proceedings of the National Academy of Sciences of the United States of America, 116(20), 10031.
    • Chicago/Turabian: Author-Date:
      Takayuki Inoue, Satoshi Saito, Masashi Tanaka, Hajime Yamakage, Toru Kusakabe, Akira Shimatsu, Masafumi Ihara, and Noriko Satoh-Asahara. 2019. “Pleiotropic Neuroprotective Effects of Taxifolin in Cerebral Amyloid Angiopathy.” Proceedings of the National Academy of Sciences of the United States of America 116 (20): 10031. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=136477257&custid=s6224580.
    • Harvard:
      Takayuki Inoue et al. (2019) ‘Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy’, Proceedings of the National Academy of Sciences of the United States of America, 116(20), p. 10031. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=136477257&custid=s6224580 (Accessed: 18 February 2020).
    • Harvard: Australian:
      Takayuki Inoue, Satoshi Saito, Masashi Tanaka, Hajime Yamakage, Toru Kusakabe, Akira Shimatsu, Masafumi Ihara & Noriko Satoh-Asahara 2019, ‘Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy’, Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 20, p. 10031, viewed 18 February 2020, .
    • MLA:
      Takayuki Inoue, et al. “Pleiotropic Neuroprotective Effects of Taxifolin in Cerebral Amyloid Angiopathy.” Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 20, May 2019, p. 10031. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=136477257&custid=s6224580.
    • Chicago/Turabian: Humanities:
      Takayuki Inoue, Satoshi Saito, Masashi Tanaka, Hajime Yamakage, Toru Kusakabe, Akira Shimatsu, Masafumi Ihara, and Noriko Satoh-Asahara. “Pleiotropic Neuroprotective Effects of Taxifolin in Cerebral Amyloid Angiopathy.” Proceedings of the National Academy of Sciences of the United States of America 116, no. 20 (May 14, 2019): 10031. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=136477257&custid=s6224580.
    • Vancouver/ICMJE:
      Takayuki Inoue, Satoshi Saito, Masashi Tanaka, Hajime Yamakage, Toru Kusakabe, Akira Shimatsu, et al. Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2019 May 14 [cited 2020 Feb 18];116(20):10031. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=136477257&custid=s6224580