Killer-cell immunoglobulin-like receptors associate with HIV-1 infection in a narrow-source Han Chinese cohort.

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  • Additional Information
    • Publication Year:
      2018
    • Author-Supplied Keywords:
      Anatomy
      Animal cells
      Biology and life sciences
      Blood
      Blood cells
      Blood plasma
      Body fluids
      Cell biology
      Cellular types
      Chinese people
      Ethnicities
      Genetic mapping
      Genetics
      Han Chinese people
      Haplotypes
      Heredity
      HIV
      HIV-1
      Immune cells
      Immunodeficiency viruses
      Immunology
      Infectious disease control
      Infectious diseases
      Lentivirus
      Medical microbiology
      Medicine and health sciences
      Microbial pathogens
      Microbiology
      NK cells
      Opportunistic infections
      Organisms
      Pathogens
      Pathology and laboratory medicine
      People and places
      Physiology
      Population groupings
      Research Article
      Retroviruses
      RNA viruses
      Viral pathogens
      Viruses
      White blood cells
    • Abstract:
      Background: The HIV pandemic remains the most serious challenge to public health worldwide. The hallmark characteristics of the disease is the eventual failure of the immune system to control opportunistic infections and death. However not everyone who has HIV develops the disease at the same rate and so we are studying how the immune system works to control the virus in those who have been infected for decades and remain relatively healthy without the need of anti-retroviral therapy (ART). Methods: Genomic DNA samples from 513 Chinese Han individuals from Henan province were typed for 15 KIR and 3 HLA class I genes. Genotype frequencies were compared between a village cohort of 261 former plasma donors (SM cohort) infected with HIV-1 through an illegal plasma donor scheme who survived more than 10 years of infection without ART and 252 ethnically-matched healthy controls from a nearby village. KIR and HLA were molecularly typed using a combination of polymerase chain reaction (PCR) with sequence-specific primers (PCR-SSP) and sequence based techniques. Results: All 15 KIR genes were observed in the study population at various frequencies. KIR2DL3 was significantly less common in the HIV-1 infected group (95.8% vs 99.2%, p = 0.021). The combination of KIR3DS1 with homozygosity for HLA-Bw4 alleles (the putative ligand for KIR3DS1) was significantly less frequent in the HIV-1 infected group than in the control group (6.0% vs 12.0% respectively, p = 0.023). Conclusion: Specific KIR-HLA compound genotypes associate with differential outcomes to infection and disease progression following exposure to a narrow-source HIV-1. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • ISSN:
      19326203
    • Accession Number:
      129101266
  • Citations
    • ABNT:
      WANG, L. et al. Killer-cell immunoglobulin-like receptors associate with HIV-1 infection in a narrow-source Han Chinese cohort. PLoS ONE, [s. l.], v. 13, n. 4, p. 1, 2018. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=129101266&custid=s6224580. Acesso em: 27 out. 2020.
    • AMA:
      Wang L, Zhang Y, Xu K, Dong T, Rowland-Jones S, Yindom L-M. Killer-cell immunoglobulin-like receptors associate with HIV-1 infection in a narrow-source Han Chinese cohort. PLoS ONE. 2018;13(4):1. Accessed October 27, 2020. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=129101266&custid=s6224580
    • APA:
      Wang, L., Zhang, Y., Xu, K., Dong, T., Rowland-Jones, S., & Yindom, L.-M. (2018). Killer-cell immunoglobulin-like receptors associate with HIV-1 infection in a narrow-source Han Chinese cohort. PLoS ONE, 13(4), 1.
    • Chicago/Turabian: Author-Date:
      Wang, Linghang, Yonghong Zhang, Keyi Xu, Tao Dong, Sarah Rowland-Jones, and Louis-Marie Yindom. 2018. “Killer-Cell Immunoglobulin-like Receptors Associate with HIV-1 Infection in a Narrow-Source Han Chinese Cohort.” PLoS ONE 13 (4): 1. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=129101266&custid=s6224580.
    • Harvard:
      Wang, L. et al. (2018) ‘Killer-cell immunoglobulin-like receptors associate with HIV-1 infection in a narrow-source Han Chinese cohort’, PLoS ONE, 13(4), p. 1. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=129101266&custid=s6224580 (Accessed: 27 October 2020).
    • Harvard: Australian:
      Wang, L, Zhang, Y, Xu, K, Dong, T, Rowland-Jones, S & Yindom, L-M 2018, ‘Killer-cell immunoglobulin-like receptors associate with HIV-1 infection in a narrow-source Han Chinese cohort’, PLoS ONE, vol. 13, no. 4, p. 1, viewed 27 October 2020, .
    • MLA:
      Wang, Linghang, et al. “Killer-Cell Immunoglobulin-like Receptors Associate with HIV-1 Infection in a Narrow-Source Han Chinese Cohort.” PLoS ONE, vol. 13, no. 4, Apr. 2018, p. 1. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=129101266&custid=s6224580.
    • Chicago/Turabian: Humanities:
      Wang, Linghang, Yonghong Zhang, Keyi Xu, Tao Dong, Sarah Rowland-Jones, and Louis-Marie Yindom. “Killer-Cell Immunoglobulin-like Receptors Associate with HIV-1 Infection in a Narrow-Source Han Chinese Cohort.” PLoS ONE 13, no. 4 (April 17, 2018): 1. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=129101266&custid=s6224580.
    • Vancouver/ICMJE:
      Wang L, Zhang Y, Xu K, Dong T, Rowland-Jones S, Yindom L-M. Killer-cell immunoglobulin-like receptors associate with HIV-1 infection in a narrow-source Han Chinese cohort. PLoS ONE [Internet]. 2018 Apr 17 [cited 2020 Oct 27];13(4):1. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=129101266&custid=s6224580