The Utility of Neutrophil to Lymphocyte Ratio as a Predictor of Intervention in Acute Diverticulitis.

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  • Additional Information
    • Publication Year:
      2017
    • Author-Supplied Keywords:
      Acute diverticulitis
      Biomarker
      Neutrophil to lymphocyte ratio
      White blood cell
    • Abstract:
      Background: Neutrophil to lymphocyte ratio (NLR) is a novel biomarker that has been recently studied in diverticulitis. The primary aim of this study was to assess the accuracy of NLR in predicting which patients had complicated diverticulitis and which patients required a radiological or surgical intervention. The accuracy of NLR was compared to C-reactive protein (CRP), white blood cell (WBC) count, neutrophil count and white cell to lymphocyte ratio (WLR). Methods: Details of all patients admitted with acute diverticulitis over an 18-month period were collected prospectively. Median CRP, WBC, neutrophil count, WLR and NLR values at initial presentation were compared using the Mann-Whitney U test. The diagnostic accuracy of each test was assessed using receiver operating characteristic curve analysis. Optimal cutoff points were determined for each biomarker using Youden's Index (J). Results: CRP, WBC, neutrophil count, WLR and NLR had variable accuracy in predicting complicated diverticulitis. NLR had the greatest accuracy of the 5 biomarkers in predicting the need for intervention with an area under the curve of 0.79 (p < 0.0001). The optimal cut-off point for NLR was 5.34 (J = 0.45). Conclusion: NLR was more accurate than CRP, WBC, neutrophil count and WLR in predicting the need for intervention. This cost-neutral, readily available biomarker can easily be calculated from the complete blood count and is a useful adjunct to CT. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • ISSN:
      02534886
    • Accession Number:
      122878488
  • Citations
    • ABNT:
      REYNOLDS, I. S. et al. The Utility of Neutrophil to Lymphocyte Ratio as a Predictor of Intervention in Acute Diverticulitis. Digestive Surgery, [s. l.], v. 34, n. 3, p. 227, 2017. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=122878488&custid=s6224580. Acesso em: 8 dez. 2019.
    • AMA:
      Reynolds IS, Heaney RM, Khan W, Khan IZ, Waldron R, Barry K. The Utility of Neutrophil to Lymphocyte Ratio as a Predictor of Intervention in Acute Diverticulitis. Digestive Surgery. 2017;34(3):227. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=122878488&custid=s6224580. Accessed December 8, 2019.
    • APA:
      Reynolds, I. S., Heaney, R. M., Khan, W., Khan, I. Z., Waldron, R., & Barry, K. (2017). The Utility of Neutrophil to Lymphocyte Ratio as a Predictor of Intervention in Acute Diverticulitis. Digestive Surgery, 34(3), 227. Retrieved from http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=122878488&custid=s6224580
    • Chicago/Turabian: Author-Date:
      Reynolds, Ian S., Roisin M. Heaney, Waqar Khan, Iqbal Z. Khan, Ronan Waldron, and Kevin Barry. 2017. “The Utility of Neutrophil to Lymphocyte Ratio as a Predictor of Intervention in Acute Diverticulitis.” Digestive Surgery 34 (3): 227. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=122878488&custid=s6224580.
    • Harvard:
      Reynolds, I. S. et al. (2017) ‘The Utility of Neutrophil to Lymphocyte Ratio as a Predictor of Intervention in Acute Diverticulitis’, Digestive Surgery, 34(3), p. 227. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=122878488&custid=s6224580 (Accessed: 8 December 2019).
    • Harvard: Australian:
      Reynolds, IS, Heaney, RM, Khan, W, Khan, IZ, Waldron, R & Barry, K 2017, ‘The Utility of Neutrophil to Lymphocyte Ratio as a Predictor of Intervention in Acute Diverticulitis’, Digestive Surgery, vol. 34, no. 3, p. 227, viewed 8 December 2019, .
    • MLA:
      Reynolds, Ian S., et al. “The Utility of Neutrophil to Lymphocyte Ratio as a Predictor of Intervention in Acute Diverticulitis.” Digestive Surgery, vol. 34, no. 3, Apr. 2017, p. 227. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=122878488&custid=s6224580.
    • Chicago/Turabian: Humanities:
      Reynolds, Ian S., Roisin M. Heaney, Waqar Khan, Iqbal Z. Khan, Ronan Waldron, and Kevin Barry. “The Utility of Neutrophil to Lymphocyte Ratio as a Predictor of Intervention in Acute Diverticulitis.” Digestive Surgery 34, no. 3 (April 2017): 227. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=122878488&custid=s6224580.
    • Vancouver/ICMJE:
      Reynolds IS, Heaney RM, Khan W, Khan IZ, Waldron R, Barry K. The Utility of Neutrophil to Lymphocyte Ratio as a Predictor of Intervention in Acute Diverticulitis. Digestive Surgery [Internet]. 2017 Apr [cited 2019 Dec 8];34(3):227. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=122878488&custid=s6224580