Neuromuscular electrical stimulation improves exercise capacity in adult patients with chronic lung disease: a meta-analysis of English studies.

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  • Additional Information
    • Affiliation:
      Department of Respiratory Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
      Department of Respiratory Disease, Liaocheng People's Hospital, Liaocheng 252000, China
      Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Background: Neuromuscular electrical stimulation (NMES) has been suggested as an alternative rehabilitative therapy to enhance exercise performance and skeletal muscle function in adult patients with chronic lung disease. However, the results of individual studies have been inconsistent. We performed a meta-analysis to evaluate the effectiveness of NMES with regard to increasing exercise capacity, quadriceps strength, muscle mass, cross-sectional area, and quality of life and decreasing dyspnea in adult patients with chronic lung disease. Methods: A systematic search was conducted of the PubMed, Cochrane Library and EMBASE databases for randomized controlled trials (RCTs) published in English-language journals before January 2018. Data were extracted using standardized forms, and the weighted mean difference (WMD) or standardized mean difference (SMD) with 95% confidence intervals (CIs) was calculated. Results: Eleven RCTs involving 368 patients were included in this meta-analysis. The pooled results showed that NMES significantly improved the 6-min walk distance (WMD: 37.93 m, 95% CI: 19.53-56.33 m; P<0.0001; P for heterogeneity =0.11; I2=47%) but not the incremental shuttle walk test (WMD: 18.18 m, 95% CI: -79.41 to 115.77 m, P=0.72; P for heterogeneity <0.0001, I²=94%) or endurance shuttle walk test (ESWT) (WMD: 96.73 m, 95% CI: -45.58 to 239.03 m, P=0.18; P heterogeneity =0.22, I²=34%). Moreover, NMES was associated with a significant improvement in quadriceps strength (SMD: 1.14, 95% CI: 0.86-1.43, P<0.00001; P heterogeneity =0.02, I²=58%). Conclusions: This systemic review and meta-analysis provided evidence supporting the beneficial role of NMES in improving exercise capacity in patients with chronic respiratory disease.
    • Journal Subset:
      Asia; Biomedical; Peer Reviewed
    • Special Interest:
      Evidence-Based Practice
    • ISSN:
      2072-1439
    • MEDLINE Info:
      NLM UID: 101533916
    • Publication Date:
      20190122
    • Publication Date:
      20190122
    • Accession Number:
      http://dx.doi.org/10.21037/jtd.2018.11.133
    • Accession Number:
      134147979
  • Citations
    • ABNT:
      HAIHONG GONG et al. Neuromuscular electrical stimulation improves exercise capacity in adult patients with chronic lung disease: a meta-analysis of English studies. Journal of Thoracic Disease, [s. l.], v. 10, n. 12, p. 6722–6732, 2018. DOI 10.21037/jtd.2018.11.133. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=ccm&AN=134147979&custid=s6224580. Acesso em: 18 fev. 2020.
    • AMA:
      Haihong Gong, Qinghe Jiang, Dongchao Shen, Jinming Gao. Neuromuscular electrical stimulation improves exercise capacity in adult patients with chronic lung disease: a meta-analysis of English studies. Journal of Thoracic Disease. 2018;10(12):6722-6732. doi:10.21037/jtd.2018.11.133.
    • APA:
      Haihong Gong, Qinghe Jiang, Dongchao Shen, & Jinming Gao. (2018). Neuromuscular electrical stimulation improves exercise capacity in adult patients with chronic lung disease: a meta-analysis of English studies. Journal of Thoracic Disease, 10(12), 6722–6732. https://doi.org/10.21037/jtd.2018.11.133
    • Chicago/Turabian: Author-Date:
      Haihong Gong, Qinghe Jiang, Dongchao Shen, and Jinming Gao. 2018. “Neuromuscular Electrical Stimulation Improves Exercise Capacity in Adult Patients with Chronic Lung Disease: A Meta-Analysis of English Studies.” Journal of Thoracic Disease 10 (12): 6722–32. doi:10.21037/jtd.2018.11.133.
    • Harvard:
      Haihong Gong et al. (2018) ‘Neuromuscular electrical stimulation improves exercise capacity in adult patients with chronic lung disease: a meta-analysis of English studies’, Journal of Thoracic Disease, 10(12), pp. 6722–6732. doi: 10.21037/jtd.2018.11.133.
    • Harvard: Australian:
      Haihong Gong, Qinghe Jiang, Dongchao Shen & Jinming Gao 2018, ‘Neuromuscular electrical stimulation improves exercise capacity in adult patients with chronic lung disease: a meta-analysis of English studies’, Journal of Thoracic Disease, vol. 10, no. 12, pp. 6722–6732, viewed 18 February 2020, .
    • MLA:
      Haihong Gong, et al. “Neuromuscular Electrical Stimulation Improves Exercise Capacity in Adult Patients with Chronic Lung Disease: A Meta-Analysis of English Studies.” Journal of Thoracic Disease, vol. 10, no. 12, Dec. 2018, pp. 6722–6732. EBSCOhost, doi:10.21037/jtd.2018.11.133.
    • Chicago/Turabian: Humanities:
      Haihong Gong, Qinghe Jiang, Dongchao Shen, and Jinming Gao. “Neuromuscular Electrical Stimulation Improves Exercise Capacity in Adult Patients with Chronic Lung Disease: A Meta-Analysis of English Studies.” Journal of Thoracic Disease 10, no. 12 (December 2018): 6722–32. doi:10.21037/jtd.2018.11.133.
    • Vancouver/ICMJE:
      Haihong Gong, Qinghe Jiang, Dongchao Shen, Jinming Gao. Neuromuscular electrical stimulation improves exercise capacity in adult patients with chronic lung disease: a meta-analysis of English studies. Journal of Thoracic Disease [Internet]. 2018 Dec [cited 2020 Feb 18];10(12):6722–32. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=ccm&AN=134147979&custid=s6224580