Immune Reconstitution Inflammatory Syndrome and the Influence of T Regulatory Cells: A Cohort Study in the Gambia.

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  • Additional Information
    • Subject Terms:
    • Abstract:
      Objective: The factors associated with the development of immune reconstitution inflammatory syndrome in HIV patients commencing antiretroviral therapy have not been fully elucidated. Using a longitudinal study design, this study addressed whether alteration in the levels of T regulatory cells contributed to the development of IRIS in a West African cohort of HIV-1 and HIV-2 patients. Seventy-one HIV infected patients were prospectively recruited to the study and followed up for six months. The patients were categorized as IRIS or non-IRIS cases following published clinical guidelines. The levels of T regulatory cells were measured using flow cytometry at baseline and all follow-up visits. Baseline cytokine levels of IL-2, IL- 6, IFN-γ, TNF-α, MIP-1β, IL-1, IL-12, IL-13, and IL-10 were measured in all patients. Results: Twenty eight percent of patients (20/71) developed IRIS and were predominantly infected with HIV-1. Patients developing IRIS had lower nadir CD4 T cells at baseline (p = 0.03) and greater CD4 T cell reconstitution (p = 0.01) at six months post-ART. However, the development of IRIS was not influenced by the levels of T regulatory cells. Similarly, baseline cytokine levels did not predict the onset of IRIS. Conclusion: The development of IRIS was not associated with differences in levels of T regulatory cells or baseline proinflammatory cytokines. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      1Medical Research Council (UK) Unit, Fajara, The Gambia
      2Institute for Tropical Medicine, Antwerp, Belgium
      3Weatherall Institute of Molecular Medicine, Medical Research Council Human Immunology Unit, John Radcliffe Hospital, Oxford, United Kingdom
      4Division of Infectious Diseases, New York University, New York, New York, United States of America
    • ISSN:
      1932-6203
    • Accession Number:
      10.1371/journal.pone.0039213
    • Accession Number:
      79826431
  • Citations
    • ABNT:
      ZAIDI, I. et al. Immune Reconstitution Inflammatory Syndrome and the Influence of T Regulatory Cells: A Cohort Study in the Gambia. PLoS ONE, [s. l.], v. 7, n. 6, p. 1–8, 2012. DOI 10.1371/journal.pone.0039213. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=a9h&AN=79826431&custid=s6224580. Acesso em: 7 abr. 2020.
    • AMA:
      Zaidi I, Peterson K, Jeffries D, et al. Immune Reconstitution Inflammatory Syndrome and the Influence of T Regulatory Cells: A Cohort Study in the Gambia. PLoS ONE. 2012;7(6):1-8. doi:10.1371/journal.pone.0039213.
    • APA:
      Zaidi, I., Peterson, K., Jeffries, D., Whittle, H., Silva, T. de, Rowland-Jones, S., Jaye, A., & Bouke C. de Jong. (2012). Immune Reconstitution Inflammatory Syndrome and the Influence of T Regulatory Cells: A Cohort Study in the Gambia. PLoS ONE, 7(6), 1–8. https://doi.org/10.1371/journal.pone.0039213
    • Chicago/Turabian: Author-Date:
      Zaidi, Irfan, Kevin Peterson, David Jeffries, Hilton Whittle, Thushan de Silva, Sarah Rowland-Jones, Assan Jaye, and Bouke C. de Jong. 2012. “Immune Reconstitution Inflammatory Syndrome and the Influence of T Regulatory Cells: A Cohort Study in the Gambia.” PLoS ONE 7 (6): 1–8. doi:10.1371/journal.pone.0039213.
    • Harvard:
      Zaidi, I. et al. (2012) ‘Immune Reconstitution Inflammatory Syndrome and the Influence of T Regulatory Cells: A Cohort Study in the Gambia’, PLoS ONE, 7(6), pp. 1–8. doi: 10.1371/journal.pone.0039213.
    • Harvard: Australian:
      Zaidi, I, Peterson, K, Jeffries, D, Whittle, H, Silva, T de, Rowland-Jones, S, Jaye, A & Bouke C. de Jong 2012, ‘Immune Reconstitution Inflammatory Syndrome and the Influence of T Regulatory Cells: A Cohort Study in the Gambia’, PLoS ONE, vol. 7, no. 6, pp. 1–8, viewed 7 April 2020, .
    • MLA:
      Zaidi, Irfan, et al. “Immune Reconstitution Inflammatory Syndrome and the Influence of T Regulatory Cells: A Cohort Study in the Gambia.” PLoS ONE, vol. 7, no. 6, June 2012, pp. 1–8. EBSCOhost, doi:10.1371/journal.pone.0039213.
    • Chicago/Turabian: Humanities:
      Zaidi, Irfan, Kevin Peterson, David Jeffries, Hilton Whittle, Thushan de Silva, Sarah Rowland-Jones, Assan Jaye, and Bouke C. de Jong. “Immune Reconstitution Inflammatory Syndrome and the Influence of T Regulatory Cells: A Cohort Study in the Gambia.” PLoS ONE 7, no. 6 (June 2012): 1–8. doi:10.1371/journal.pone.0039213.
    • Vancouver/ICMJE:
      Zaidi I, Peterson K, Jeffries D, Whittle H, Silva T de, Rowland-Jones S, et al. Immune Reconstitution Inflammatory Syndrome and the Influence of T Regulatory Cells: A Cohort Study in the Gambia. PLoS ONE [Internet]. 2012 Jun [cited 2020 Apr 7];7(6):1–8. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=a9h&AN=79826431&custid=s6224580