Wash functions downstream of Rho and links linear and branched actin nucleation factors.

Item request has been placed! ×
Item request cannot be made. ×
  Processing Request
  • Additional Information
    • Author-Supplied Keywords:
      Actin nucleation
      Arp2/3
      Drosophila
      Rho1 GTPase
      Spire
      Wash
      Wiskott Aldrich Syndrome
    • Abstract:
      Wiskott-Aldrich Syndrome (WAS) family proteins are Arp2/3 activators that mediate the branched-actin network formation required for cytoskeletal remodeling, intracellular transport and cell locomotion. Wasp and Scar/WAVE, the two founding members of the family, are regulated by the GTPases Cdc42 and Rac, respectively. By contrast, linear actin nucleators, such as Spire and formins, are regulated by the GTPase Rho. We recently identified a third WAS family member, called Wash, with Arp2/3-mediated actin nucleation activity. We show that Drosophila Wash interacts genetically with Arp2/3, and also functions downstream of Rho1 with Spire and the formin Cappuccino to control actin and microtubule dynamics during Drosophila oogenesis. Wash bundles and crosslinks F-actin and microtubules, is regulated by Rho1, Spire and Arp2/3, and is essential for actin cytoskeleton organization in the egg chamber. Our results establish Wash and Rho as regulators of both linear- and branched-actin networks, and suggest an Arp2/3-mediated mechanism for how cells might coordinately regulate these structures. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Development (09501991) is the property of Company of Biologists Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    • ISSN:
      0950-1991
    • Accession Number:
      10.1242/dev.035246
    • Accession Number:
      43589285
  • Citations
    • ABNT:
      LIU, R. et al. Wash functions downstream of Rho and links linear and branched actin nucleation factors. Development (09501991), [s. l.], v. 136, n. 16, p. 1, 2009. DOI 10.1242/dev.035246. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=a9h&AN=43589285&custid=s6224580. Acesso em: 14 dez. 2019.
    • AMA:
      Liu R, Abreu-Blanco MT, Barry KC, Linardopoulou EV, Osborn GE, Parkhurst SM. Wash functions downstream of Rho and links linear and branched actin nucleation factors. Development (09501991). 2009;136(16):1. doi:10.1242/dev.035246.
    • APA:
      Liu, R., Abreu-Blanco, M. T., Barry, K. C., Linardopoulou, E. V., Osborn, G. E., & Parkhurst, S. M. (2009). Wash functions downstream of Rho and links linear and branched actin nucleation factors. Development (09501991), 136(16), 1. https://doi.org/10.1242/dev.035246
    • Chicago/Turabian: Author-Date:
      Liu, Raymond, Maria Teresa Abreu-Blanco, Kevin C. Barry, Elena V. Linardopoulou, Gregory E. Osborn, and Susan M. Parkhurst. 2009. “Wash Functions Downstream of Rho and Links Linear and Branched Actin Nucleation Factors.” Development (09501991) 136 (16): 1. doi:10.1242/dev.035246.
    • Harvard:
      Liu, R. et al. (2009) ‘Wash functions downstream of Rho and links linear and branched actin nucleation factors’, Development (09501991), 136(16), p. 1. doi: 10.1242/dev.035246.
    • Harvard: Australian:
      Liu, R, Abreu-Blanco, MT, Barry, KC, Linardopoulou, EV, Osborn, GE & Parkhurst, SM 2009, ‘Wash functions downstream of Rho and links linear and branched actin nucleation factors’, Development (09501991), vol. 136, no. 16, p. 1, viewed 14 December 2019, .
    • MLA:
      Liu, Raymond, et al. “Wash Functions Downstream of Rho and Links Linear and Branched Actin Nucleation Factors.” Development (09501991), vol. 136, no. 16, Aug. 2009, p. 1. EBSCOhost, doi:10.1242/dev.035246.
    • Chicago/Turabian: Humanities:
      Liu, Raymond, Maria Teresa Abreu-Blanco, Kevin C. Barry, Elena V. Linardopoulou, Gregory E. Osborn, and Susan M. Parkhurst. “Wash Functions Downstream of Rho and Links Linear and Branched Actin Nucleation Factors.” Development (09501991) 136, no. 16 (August 15, 2009): 1. doi:10.1242/dev.035246.
    • Vancouver/ICMJE:
      Liu R, Abreu-Blanco MT, Barry KC, Linardopoulou EV, Osborn GE, Parkhurst SM. Wash functions downstream of Rho and links linear and branched actin nucleation factors. Development (09501991) [Internet]. 2009 Aug 15 [cited 2019 Dec 14];136(16):1. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=a9h&AN=43589285&custid=s6224580