Premature Ventricular Complex is More Prevalent During Acute Exacerbated than Stable States of Chronic Obstructive Pulmonary Disease, and Is Related to Cardiac Troponin T.

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  • Additional Information
    • Author-Supplied Keywords:
      Acute exacerbation of COPD
      cardiac arrhythmias
      electrocardiography
    • Abstract:
      During acute exacerbation of chronic obstructive pulmonary disease (AECOPD), myocardial stress may be aggravated. Sparse data exist concerning the prevalence and correlates of cardiac arrhythmias in the stable and exacerbated states of COPD. We hypothesized that AECOPD is associated with increased prevalence of cardiac arrhythmias independent of COPD-severity and co-morbidity, and explored possible mechanisms. A 24-hour Holter recording was obtained in 74 patients with stable COPD and 45 patients with AECOPD (mean age 54 years, 56% women). Any incidence of supraventricular tachycardia (SVT), frequent premature ventricular complex (PVC, >30/hour) and complex ventricular ectopy (bigeminy, trigeminy or non-sustained ventricular tachycardia) was recorded and compared between the two groups. Adjustments were made for by stable disease-related co-variates (demography, co-morbidity, COPD-severity) and by acute disease-related co-variates (heart rate, cardiac troponin T (cTnT), PO2, PCO2and C-reactive protein (CRP)) in explorative analyses. The prevalence of SVT, frequent PVCs or complex ventricular ectopy was 40%, 27% and 33% in AECOPD, and 31%, 31% and 12% in stable COPD, respectively. Frequent PVC, but not SVT or complex ventricular ectopy, was significantly increased in AECOPD compared to stable COPD, odds ratio 3.03 (1.03–10.5,p= 0.039) when adjusted for stable disease-related co-variates. Higher heart rate, cTnT and CRP attenuated the association between AECOPD and frequent PVC to non-significant, while heart rate remained associated with frequent PVC. In conclusion, frequent PVC is more prevalent in exacerbated than in the stable states of COPD. Attenuation effects of cTnT, tachycardia and CRP suggest that cardiac stress or inflammation may be involved in mechanisms causing frequent PVC i AECOPD. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      1Division of Medicine, Akershus University Hospital, Lørenskog, Norway
      2Center for Heart Failure Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
      3LHL-klinikkene, Glittre, Hakadal, Norway
      4Department of Radiology, Akershus University Hospital, Lørenskog, Norway
    • Full Text Word Count:
      4279
    • ISSN:
      1541-2555
    • Accession Number:
      10.1080/15412555.2017.1298085
    • Accession Number:
      123287934
  • Citations
    • ABNT:
      EINVIK, G. et al. Premature Ventricular Complex is More Prevalent During Acute Exacerbated than Stable States of Chronic Obstructive Pulmonary Disease, and Is Related to Cardiac Troponin T. COPD: Journal of Chronic Obstructive Pulmonary Disease, [s. l.], v. 14, n. 3, p. 318–323, 2017. DOI 10.1080/15412555.2017.1298085. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=a9h&AN=123287934&custid=s6224580. Acesso em: 20 jan. 2020.
    • AMA:
      Einvik G, Bhatnagar R, Holmedahl NH, Neukamm A, Omland T, Søyseth V. Premature Ventricular Complex is More Prevalent During Acute Exacerbated than Stable States of Chronic Obstructive Pulmonary Disease, and Is Related to Cardiac Troponin T. COPD: Journal of Chronic Obstructive Pulmonary Disease. 2017;14(3):318-323. doi:10.1080/15412555.2017.1298085.
    • APA:
      Einvik, G., Bhatnagar, R., Holmedahl, N. H., Neukamm, A., Omland, T., & Søyseth, V. (2017). Premature Ventricular Complex is More Prevalent During Acute Exacerbated than Stable States of Chronic Obstructive Pulmonary Disease, and Is Related to Cardiac Troponin T. COPD: Journal of Chronic Obstructive Pulmonary Disease, 14(3), 318–323. https://doi.org/10.1080/15412555.2017.1298085
    • Chicago/Turabian: Author-Date:
      Einvik, Gunnar, Rahul Bhatnagar, Nils Henrik Holmedahl, Anke Neukamm, Torbjørn Omland, and Vidar Søyseth. 2017. “Premature Ventricular Complex Is More Prevalent During Acute Exacerbated than Stable States of Chronic Obstructive Pulmonary Disease, and Is Related to Cardiac Troponin T.” COPD: Journal of Chronic Obstructive Pulmonary Disease 14 (3): 318–23. doi:10.1080/15412555.2017.1298085.
    • Harvard:
      Einvik, G. et al. (2017) ‘Premature Ventricular Complex is More Prevalent During Acute Exacerbated than Stable States of Chronic Obstructive Pulmonary Disease, and Is Related to Cardiac Troponin T’, COPD: Journal of Chronic Obstructive Pulmonary Disease, 14(3), pp. 318–323. doi: 10.1080/15412555.2017.1298085.
    • Harvard: Australian:
      Einvik, G, Bhatnagar, R, Holmedahl, NH, Neukamm, A, Omland, T & Søyseth, V 2017, ‘Premature Ventricular Complex is More Prevalent During Acute Exacerbated than Stable States of Chronic Obstructive Pulmonary Disease, and Is Related to Cardiac Troponin T’, COPD: Journal of Chronic Obstructive Pulmonary Disease, vol. 14, no. 3, pp. 318–323, viewed 20 January 2020, .
    • MLA:
      Einvik, Gunnar, et al. “Premature Ventricular Complex Is More Prevalent During Acute Exacerbated than Stable States of Chronic Obstructive Pulmonary Disease, and Is Related to Cardiac Troponin T.” COPD: Journal of Chronic Obstructive Pulmonary Disease, vol. 14, no. 3, June 2017, pp. 318–323. EBSCOhost, doi:10.1080/15412555.2017.1298085.
    • Chicago/Turabian: Humanities:
      Einvik, Gunnar, Rahul Bhatnagar, Nils Henrik Holmedahl, Anke Neukamm, Torbjørn Omland, and Vidar Søyseth. “Premature Ventricular Complex Is More Prevalent During Acute Exacerbated than Stable States of Chronic Obstructive Pulmonary Disease, and Is Related to Cardiac Troponin T.” COPD: Journal of Chronic Obstructive Pulmonary Disease 14, no. 3 (June 2017): 318–23. doi:10.1080/15412555.2017.1298085.
    • Vancouver/ICMJE:
      Einvik G, Bhatnagar R, Holmedahl NH, Neukamm A, Omland T, Søyseth V. Premature Ventricular Complex is More Prevalent During Acute Exacerbated than Stable States of Chronic Obstructive Pulmonary Disease, and Is Related to Cardiac Troponin T. COPD: Journal of Chronic Obstructive Pulmonary Disease [Internet]. 2017 Jun [cited 2020 Jan 20];14(3):318–23. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=a9h&AN=123287934&custid=s6224580