IL-1α Signaling Initiates the Inflammatory Response to Virulent Legionella pneumophila In Vivo.

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  • Additional Information
    • Abstract:
      Legionella pneumophila is an intracellular bacterial pathogen that is the cause of a severe pneumonia in humans called Legionnaires' disease. A key feature of L. pneumophila pathogenesis is the rapid influx of neutrophils into the lungs, which occurs in response to signaling via the IL-1R. Two distinct cytokines, IL-1α and IL-1β, can stimulate the type I IL-1R. IL-1β is produced upon activation of cytosolic sensors called inflammasomes that detect L. pneumophila in vitro and in vivo. Surprisingly, we find no essential role for IL-1β in neutrophil recruitment to the lungs in response to L. pneumophila. Instead, we show that IL-1α is a critical initiator of neutrophil recruitment to the lungs of L. pneumophila-infected mice. We find that neutrophil recruitment in response to virulent L. pneumophila requires the production of IL-1α specifically by hematopoietic cells. In contrast to IL-1β, the innate signaling pathways that lead to the production of IL-1α in response to L. pneumophila remain poorly defined. In particular, although we confirm a role for inflammasomes for initiation of IL-1β signaling in vivo, we find no essential role for inflammasomes in production of IL-1α. Instead, we propose that a novel host pathway, perhaps involving inhibition of host protein synthesis, is responsible for IL-1α production in response to virulent L. pneumophila. Our results establish IL-1α as a critical initiator of the inflammatory response to L. pneumophila in vivo and point to an important role for IL-1α in providing an alternative to inflammasome-mediated immune responses in vivo. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      1Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720
      2Graduate Group of Infectious Diseases and Immunity, School of Public Health, University of California, Berkeley, Berkeley, CA 94720
      3Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111
      4Department of Natural Sciences, Assumption College, Worcester, MA
    • ISSN:
      0022-1767
    • Accession Number:
      10.4049/jimmunol.1300100
    • Accession Number:
      103637448
  • Citations
    • ABNT:
      BARRY, K. C. et al. IL-1α Signaling Initiates the Inflammatory Response to Virulent Legionella pneumophila In Vivo. Journal of Immunology, [s. l.], v. 190, n. 12, p. 6329–6339, 2013. DOI 10.4049/jimmunol.1300100. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=a9h&AN=103637448&custid=s6224580. Acesso em: 7 dez. 2019.
    • AMA:
      Barry KC, Fontana MF, Portman JL, Dugan AS, Vance RE. IL-1α Signaling Initiates the Inflammatory Response to Virulent Legionella pneumophila In Vivo. Journal of Immunology. 2013;190(12):6329-6339. doi:10.4049/jimmunol.1300100.
    • APA:
      Barry, K. C., Fontana, M. F., Portman, J. L., Dugan, A. S., & Vance, R. E. (2013). IL-1α Signaling Initiates the Inflammatory Response to Virulent Legionella pneumophila In Vivo. Journal of Immunology, 190(12), 6329–6339. https://doi.org/10.4049/jimmunol.1300100
    • Chicago/Turabian: Author-Date:
      Barry, Kevin C., Mary F. Fontana, Jonathan L. Portman, Aisling S. Dugan, and Russell E. Vance. 2013. “IL-1α Signaling Initiates the Inflammatory Response to Virulent Legionella Pneumophila In Vivo.” Journal of Immunology 190 (12): 6329–39. doi:10.4049/jimmunol.1300100.
    • Harvard:
      Barry, K. C. et al. (2013) ‘IL-1α Signaling Initiates the Inflammatory Response to Virulent Legionella pneumophila In Vivo’, Journal of Immunology, 190(12), pp. 6329–6339. doi: 10.4049/jimmunol.1300100.
    • Harvard: Australian:
      Barry, KC, Fontana, MF, Portman, JL, Dugan, AS & Vance, RE 2013, ‘IL-1α Signaling Initiates the Inflammatory Response to Virulent Legionella pneumophila In Vivo’, Journal of Immunology, vol. 190, no. 12, pp. 6329–6339, viewed 7 December 2019, .
    • MLA:
      Barry, Kevin C., et al. “IL-1α Signaling Initiates the Inflammatory Response to Virulent Legionella Pneumophila In Vivo.” Journal of Immunology, vol. 190, no. 12, June 2013, pp. 6329–6339. EBSCOhost, doi:10.4049/jimmunol.1300100.
    • Chicago/Turabian: Humanities:
      Barry, Kevin C., Mary F. Fontana, Jonathan L. Portman, Aisling S. Dugan, and Russell E. Vance. “IL-1α Signaling Initiates the Inflammatory Response to Virulent Legionella Pneumophila In Vivo.” Journal of Immunology 190, no. 12 (June 15, 2013): 6329–39. doi:10.4049/jimmunol.1300100.
    • Vancouver/ICMJE:
      Barry KC, Fontana MF, Portman JL, Dugan AS, Vance RE. IL-1α Signaling Initiates the Inflammatory Response to Virulent Legionella pneumophila In Vivo. Journal of Immunology [Internet]. 2013 Jun 15 [cited 2019 Dec 7];190(12):6329–39. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=a9h&AN=103637448&custid=s6224580